Which adverse effect would most likely necessitate discontinuing isoniazid therapy?

Which adverse effect would most likely necessitate discontinuing isoniazid therapy?

• A. Jaundice
• B. Nausea
• C. Rash
• D. Headache

Answer: (A)

Hepatotoxicity from isoniazid is the key risk to recognize. Isoniazid is processed in the liver, and it can cause liver injury that ranges from elevated liver enzymes to acute hepatitis. Jaundice is a clear sign of hepatic dysfunction and indicates significant liver injury, so stopping isoniazid is the appropriate action to prevent further harm. Other common adverse effects like nausea, rash, or headache can occur but do not by themselves signal serious liver damage and don’t automatically require stopping the drug unless they are severe or accompanied by other liver-related symptoms. Monitoring liver function and watching for jaundice are essential when a patient is on isoniazid.

Hepatotoxicity from isoniazid is the key risk to recognize. Isoniazid is processed in the liver, and it can cause liver injury that ranges from elevated liver enzymes to acute hepatitis. Jaundice is a clear sign of hepatic dysfunction and indicates significant liver injury, so stopping isoniazid is the appropriate action to prevent further harm. Other common adverse effects like nausea, rash, or headache can occur but do not by themselves signal serious liver damage and don’t automatically require stopping the drug unless they are severe or accompanied by other liver-related symptoms. Monitoring liver function and watching for jaundice are essential when a patient is on isoniazid.